Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Canada.
World J Biol Psychiatry. 2012 Jan;13(1):65-74. doi: 10.3109/15622975.2010.543431. Epub 2011 Jan 19.
Excessive or deficient levels of extracellular dopamine have been hypothesized to contribute to a broad spectrum of mood, motor, and thought abnormalities, and dopaminergic system genes have been implicated in aggressive behaviour from animal and human studies. OBJECTIVE. We examined selected members of the dopaminergic system genes for association with child aggression.
We analyzed polymorphisms in the dopamine transporter DAT1/SLC6A3, dopamine receptor DRD2, and DRD4 genes in our sample of pervasive childhood aggression consisting of 144 cases paired with 144 healthy controls, matched for sex and ethnicity.
Aggressive children were significantly more likely to have the at least one copy of the G allele for the DRD2 A-241G polymorphism (genotypic P=0.02; allelic P=0.01). The DRD2 rs1079598 CC genotype was overrepresented in aggressive children compared to controls (genotype P=0.04). The DRD2 TaqIA T allele (P=0.01) and the TT genotype (P=0.01) were also significantly overrepresented in aggressive children.
Our preliminary results suggest that three polymorphisms in DRD2 are associated with childhood aggression. Future studies are required to replicate the current results and to further explore the relationship between the dopamine system and aggressive behaviour in children.
据推测，细胞外多巴胺水平过高或过低与广泛的情绪、运动和思维异常有关，多巴胺能系统基因已被动物和人类研究暗示与攻击行为有关。
目的。我们研究了多巴胺能系统基因的一些成员与儿童攻击行为的相关性。
方法。我们分析了多巴胺转运蛋白 DAT1/SLC6A3、多巴胺受体 DRD2 和 DRD4 基因在我们的广泛儿童攻击行为样本中的多态性，该样本包括 144 例病例和 144 例健康对照，按性别和种族匹配。
结果。具有 DRD2 A-241G 多态性至少一个 G 等位基因的攻击儿童明显更有可能（基因型 P=0.02；等位基因 P=0.01）。与对照组相比，具有 DRD2 rs1079598 CC 基因型的攻击儿童明显更多（基因型 P=0.04）。DRD2 TaqIA T 等位基因（P=0.01）和 TT 基因型（P=0.01）在攻击儿童中也明显更为常见。
结论。我们的初步结果表明，DRD2 中的三个多态性与儿童攻击行为有关。需要进一步的研究来复制当前的结果，并进一步探索多巴胺系统与儿童攻击行为之间的关系。
