甲型流感病毒 M2 质子通道的功能和抑制的结构与动力学机制。
Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus.
机构信息
Department of chemistry, University of Pennsylvania, 231 south, 34th st, Philadelphia, PA 19104, USA.
出版信息
Curr Opin Struct Biol. 2011 Feb;21(1):68-80. doi: 10.1016/j.sbi.2010.12.002. Epub 2011 Jan 17.
Abstract
The M2 proton channel from influenza A virus, a prototype for a class of viral ion channels known as viroporins, conducts protons along a chain of water molecules and ionizable sidechains, including His37. Recent studies highlight a delicate interplay between protein folding, proton binding, and proton conduction through the channel. Drugs inhibit proton conduction by binding to an aqueous cavity adjacent to M2's proton-selective filter, thereby blocking access of proton to the filter, and altering the energetic landscape of the channel and the energetics of proton-binding to His37.
摘要
甲型流感病毒的 M2 质子通道是一类被称为病毒离子通道的病毒通道的原型，它沿着一系列水分子和可离子化侧链（包括 His37）传导质子。最近的研究强调了蛋白质折叠、质子结合以及质子通过通道传导之间的微妙相互作用。药物通过与 M2 的质子选择性过滤器相邻的水腔结合来抑制质子传导，从而阻止质子进入过滤器，并改变通道的能量景观以及质子与 His37 结合的能量。
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