威尔姆斯瘤：关于肿瘤抑制基因、癌基因和变色龙基因。
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.
机构信息
Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
出版信息
Nat Rev Cancer. 2011 Feb;11(2):111-21. doi: 10.1038/nrc3002. Epub 2011 Jan 20.
Abstract
Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?
摘要
在维尔姆斯瘤中鉴定出的突变基因包括 TP53，一个经典的肿瘤抑制基因（TSG）；CTNNB1（编码β-连环蛋白），一个经典的癌基因；WTX，越来越多的数据表明它是一个 TSG；以及 WT1，它在一些维尔姆斯瘤中失活，类似于 TSG。然而，WT1 并不总是符合 TSG 标签，有些数据表明 WT1 增强细胞存活和增殖，类似于癌基因。WT1 是变色龙吗，根据细胞环境，它可以作为 TSG 或癌基因发挥作用？这些标签是否甚至适合描述和理解 WT1 的功能？
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