Department of Nutrition, Food and Exercise Sciences, Florida State University, 120 Convocation Way, Tallahassee, FL 32306-1493, USA.
Eur J Appl Physiol. 2011 Sep;111(9):1965-71. doi: 10.1007/s00421-011-1832-4. Epub 2011 Jan 20.
Arterial stiffness and hemodynamics may be increased following a bout of resistance exercise. Oral creatine supplementation (Cr) may attenuate cardiovascular responses after exercise via improved anaerobic metabolism. This study was aimed to determine the effect of Cr on hemodynamic and arterial stiffness responses after acute isokinetic exercise. Sixteen healthy males (22.6 ± 0.6 year) were randomly assigned to either placebo (Pl, n = 8) or Cr (n = 8) (2 × 5 g/day) for 3 weeks. Brachial systolic blood pressure (SBP), heart rate (HR), brachial-ankle pulse wave velocity (baPWV), and leg PWV were measured in the supine position at rest before and after the interventions. After the supplementation period, parameters were also measured 5 min (PE5) and 15 min (PE15) after two sets of leg isokinetic exercise. There was no difference between the groups in resting measurements before and after the supplementation. Compared with the Pl group, the Cr group had attenuated (P < 0.05) increases in SBP at PE5 (Pl 14.0 ± 2.5, Cr 5.6 ± 2.3 mmHg), HR at both P5 (Pl 28 ± 4 vs. Cr 16 ± 2 beats/min) and PE15 (Pl 21 ± 3, Cr 11 ± 2 beats/min) and rate pressure product at P5 (Pl 45.8 ± 6.4, Cr 24.8 ± 2.2) and P15 (Pl 34.2 ± 5.0, Cr 15.9 ± 6.0). Compared with the Pl group, the Cr group had suppressed increases in baPWV at PE5 (Pl 1.5 ± 0.4, Cr -0.1 ± 0.4 m/s) and PE15 (Pl 1.1 ± 0.2, Cr -0.3 ± 0.3 m/s) and returned SBP to pre-exercise values at PE15 (Pl 10.6 ± 2.8, Cr 2.1 ± 2.6 mmHg). PWV in the exercised leg decreased at PE5 in both groups. These findings suggest that Cr supplementation attenuates the hemodynamic and baPWV responses after acute isokinetic exercise.
动脉僵硬度和血液动力学可能会在一次抗阻运动后增加。口服肌酸补充剂 (Cr) 可通过改善无氧代谢来减轻运动后的心血管反应。本研究旨在确定 Cr 对急性等动运动后血液动力学和动脉僵硬度反应的影响。16 名健康男性（22.6 ± 0.6 岁）被随机分为安慰剂（Pl，n = 8）或 Cr（n = 8）（每天 2 × 5 g）3 周。在干预前后，仰卧位休息时测量肱动脉收缩压（SBP）、心率（HR）、肱踝脉搏波速度（baPWV）和腿 PWV。补充期后，两组在两组腿部等动运动后 5 分钟（PE5）和 15 分钟（PE15）时也测量了这些参数。补充前后两组在静息测量时无差异。与 Pl 组相比，Cr 组在 PE5 时 SBP 升高幅度降低（Pl 14.0 ± 2.5，Cr 5.6 ± 2.3 mmHg），PE5 和 PE15 时 HR 升高幅度降低（Pl 28 ± 4 与 Cr 16 ± 2 次/分钟）和 RPP 在 P5（Pl 45.8 ± 6.4，Cr 24.8 ± 2.2）和 P15（Pl 34.2 ± 5.0，Cr 15.9 ± 6.0）。与 Pl 组相比，Cr 组在 PE5（Pl 1.5 ± 0.4，Cr -0.1 ± 0.4 m/s）和 PE15（Pl 1.1 ± 0.2，Cr -0.3 ± 0.3 m/s）时 baPWV 升高幅度降低，并且在 PE15 时 SBP 恢复到运动前水平（Pl 10.6 ± 2.8，Cr 2.1 ± 2.6 mmHg）。在两组中，运动腿的 PWV 在 PE5 时降低。这些发现表明，Cr 补充剂可减轻急性等动运动后的血液动力学和 baPWV 反应。
