Arenas-Gamboa A M, Mansell J
Texas Veterinary Medical Center, Texas A&M University, College Station, TX 77843-4467, USA.
J Comp Pathol. 2011 May;144(4):328-33. doi: 10.1016/j.jcpa.2010.10.011. Epub 2011 Jan 19.
Haemangiosarcomas (HSAs) are malignant tumours of endothelial cell origin. Epithelioid HSA is a variant of the histologically conventional HSA that has little or no morphological evidence of a vascular origin and has been reported rarely in domestic animals. The following report documents six cases of equine epithelioid HSA occurring in the ocular tissues of horses with a mean age of 19.8 years at the time of diagnosis. Microscopically, all of the lesions consisted of solid sheets or cords of epithelioid cells with rare narrow clefts or small spaces containing erythrocytes that were often the only feature indicating a vascular origin. On immunohistochemistry, the neoplastic cells expressed vimentin, CD31 and factor VIII-related antigen, but not cytokeratin, indicating an endothelial nature.
血管肉瘤（HSAs）是内皮细胞起源的恶性肿瘤。上皮样血管肉瘤是组织学上传统血管肉瘤的一种变体，几乎没有或没有血管起源的形态学证据，在家畜中鲜有报道。以下报告记录了6例发生于马眼组织的马上皮样血管肉瘤病例，诊断时的平均年龄为19.8岁。镜下，所有病变均由上皮样细胞的实性片层或条索组成，偶见狭窄裂隙或含有红细胞的小间隙，这些往往是表明血管起源的唯一特征。免疫组化显示，肿瘤细胞表达波形蛋白、CD31和VIII因子相关抗原，但不表达细胞角蛋白，表明其具有内皮性质。
