COPD 患者静息和运动时的握力和心脏功能受损。

Resting handgrip force and impaired cardiac function at rest and during exercise in COPD patients.

机构信息

Division of Pulmonary, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA.

出版信息

Respir Med. 2011 May;105(5):748-54. doi: 10.1016/j.rmed.2010.12.011. Epub 2011 Jan 19.

DOI:10.1016/j.rmed.2010.12.011

PMID:21251806

Abstract

BACKGROUND

Cardiac function measured as the oxygen pulse (O(2) pulse) is impaired during exercise (CPET) in patients with COPD. We investigated the relationship between handgrip force and O(2) pulse in COPD and controls.

METHODS

We measured anthropometrics, lung function, respiratory muscle force, handgrip (HG) force and fat free mass (FFM) at rest in 18 men with COPD (FEV(1)%=45±20) and 15 controls. We then performed a symptom limited cardiopulmonary exercise test (CPET) with similar load and used heart rate, and oxygen pulse (VO(2)/HR) to express cardiac function at rest and during exercise. We corrected the O(2) pulse by FFM.

RESULTS

Patients and controls were similar in BMI and FFM. COPD patients had lower handgrip (37.8±7 vs. 55±2) kg. O(2) pulse and HG were associated (r=0.665). At rest, COPD patients had faster heart rate (76±11 vs. 61±5) and lower oxygen pulse. COPD patients had lower oxygen pulse mL/beat at exercise isotime (10.6±3.7 vs. 14.3±2.7), even adjusted by muscle mass.

CONCLUSION

Handgrip is associated with impaired heart function at rest and during exercise in COPD patients even adjusting for muscle mass differences. Lower handgrip may be a marker of impaired cardiac function in COPD patients.

摘要

背景

在 COPD 患者的运动心肺测试（CPET）中，心脏功能的测量值（即氧脉冲（O(2)脉冲））受损。我们研究了 COPD 患者和对照组的握力与 O(2)脉冲之间的关系。

方法

我们测量了 18 名男性 COPD 患者（FEV(1)%=45±20）和 15 名对照组在静息时的人体测量学、肺功能、呼吸肌力量、握力（HG）和去脂体重（FFM）。然后，我们进行了一项症状限制心肺运动测试（CPET），使用相似的负荷，并使用心率和氧脉冲（VO(2)/HR）来表示静息和运动时的心脏功能。我们通过 FFM 对 O(2)脉冲进行了校正。

结果

患者和对照组在 BMI 和 FFM 方面相似。COPD 患者的握力较低（37.8±7 与 55±2 kg）。O(2)脉冲和 HG 相关（r=0.665）。在静息时，COPD 患者的心率较快（76±11 与 61±5 bpm），氧脉冲较低。即使调整肌肉质量，COPD 患者在运动等时的氧脉冲 mL/beat 也较低（10.6±3.7 与 14.3±2.7）。