我们为你提供了“保护伞”：脑膜如何控制大脑发育。
We have got you 'covered': how the meninges control brain development.
机构信息
Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA 94158, United States.
出版信息
Curr Opin Genet Dev. 2011 Jun;21(3):249-55. doi: 10.1016/j.gde.2010.12.005. Epub 2011 Jan 20.
Abstract
The meninges have traditionally been viewed as specialized membranes surrounding and protecting the adult brain from injury. However, there is increasing evidence that the fetal meninges play important roles during brain development. Through the release of diffusible factors, the meninges influence the proliferative and migratory behaviors of neural progenitors and neurons in the forebrain and hindbrain. Meningeal cells also secrete and organize the pial basement membrane (BM), a critical anchor point for the radially oriented fibers of neuroepithelial stem cells. With its emerging role in brain development, the potential that defects in meningeal development may underlie certain congenital brain abnormalities in humans should be considered. In this review, we will discuss what is known about assembly of the fetal meninges and review the role of meningeal-derived proteins in mouse and human brain development.
摘要
脑膜传统上被视为围绕和保护成人大脑免受损伤的特殊膜。然而，越来越多的证据表明，胎儿脑膜在大脑发育过程中发挥着重要作用。通过释放可扩散因子，脑膜影响前脑和后脑神经祖细胞和神经元的增殖和迁移行为。脑膜细胞还分泌和组织软脑膜基底膜 (BM)，这是神经上皮干细胞径向定向纤维的关键锚定点。随着其在大脑发育中的作用不断显现，脑膜发育缺陷可能是人类某些先天性脑异常的基础，这一点应该得到考虑。在这篇综述中，我们将讨论胎儿脑膜的组装情况，并回顾脑膜衍生蛋白在小鼠和人类大脑发育中的作用。
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