Kardiologische Praxis und Praxisklinik, Munich, Germany.
EuroIntervention. 2011 Feb;6(7):819-25. doi: 10.4244/EIJV6I7A141.
e-HEALING is a worldwide, internet-based registry designed to capture post marketing clinical data on the use of the Genous™ EPC capturing R stent™. Rapid restoration of a healthy endothelial layer after stent placement by capturing circulating endothelial progenitor cells may reduce both stent thrombosis (ST) and in-stent-restenosis.
We planned a 5,000 patient registry with ≥1 lesion suitable for stenting. The 12-month primary outcome was target vessel failure (TVF), defined as target vessel-related cardiac death or myocardial infarction (MI) and target vessel revascularisation. Secondary outcomes were the composite of cardiac death, MI or target lesion revascularisation (TLR), and individual outcomes including ST. A total of 4,939 patients received ≥1 Genous stent between 2005 and 2007. Baseline characteristics showed a median age of 63 years, 79% males, 25% diabetics, and 37% with prior MI. A total of 49% of lesions treated were ACC/AHA type B2 or C; 1.1 stents per lesion were used. At 12 months, TVF occurred in 8.4% and the composite of cardiac death, MI or TLR in 7.9%. Twelve-month TLR and ST were 5.7% and 1.1%, respectively.
Coronary stenting with the Genous results in good clinical outcomes, and low incidences of repeat revascularisation and ST.
e-HEALING 是一个全球性的基于互联网的注册系统，旨在收集 Genous™ EPC 捕获 R 支架™ 上市后临床使用的数据。支架置入后通过捕获循环内皮祖细胞快速恢复健康的内皮层，可能会降低支架血栓形成（ST）和支架内再狭窄的风险。
我们计划开展一个 5000 例患者的注册研究，每个患者至少有 1 个适合支架置入的病变。12 个月的主要终点是靶血管失败（TVF），定义为靶血管相关的心脏死亡、心肌梗死（MI）和靶血管血运重建。次要终点是心脏死亡、MI 或靶病变血运重建（TLR）的复合终点，以及包括 ST 的单个终点。2005 年至 2007 年间，共有 4939 例患者接受了至少 1 枚 Genous 支架。基线特征显示，中位年龄为 63 岁，79%为男性，25%为糖尿病患者，37%有既往 MI。接受治疗的病变中，49%为 ACC/AHA 类型 B2 或 C；每例病变平均使用 1.1 枚支架。12 个月时，TVF 发生率为 8.4%，心脏死亡、MI 或 TLR 的复合终点发生率为 7.9%。12 个月时 TLR 和 ST 的发生率分别为 5.7%和 1.1%。
冠状动脉支架置入术采用 Genous 支架可获得良好的临床结果，且再血管化和 ST 的发生率较低。
