South Australian Institute of Ophthalmology, c/o Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000, Australia.
Br J Ophthalmol. 2011 Jul;95(7):947-50. doi: 10.1136/bjo.2010.186171. Epub 2011 Jan 20.
To report the outcome of treatment of localised non-invasive ocular surface squamous neoplasia (OSSN) where topical 5-fluorouracil (5-FU 1%) is used as an adjuvant to surgical excision.
The study was a prospective non-comparative interventional case series. 55 cases of primary localised OSSN and 10 cases of recurrent localised OSSN were treated with excision, cryotherapy and adjuvant 5-FU 1%. In all cases, irrespective of the involvement of surgical margins, a single cycle of 5-FU 1% was administered, four times a day for 2 weeks continuously. The main outcome measures were (1) recurrence and (2) complications related to adjuvant topical chemotherapy. Individuals were reviewed for a minimum of 12 months.
There was a single case of recurrence (1.5%). 57% of patients had short-term complications secondary to 5-FU 1%, most frequently lid toxicity (49%), followed by superficial keratitis, epiphora and corneal epithelial defects. Four patients were unable to complete the course of 5-FU 1% because of local toxicity.
The management of localised non-invasive OSSN with adjuvant 5-FU 1% was associated with a low rate of local recurrence. Although 5-FU 1% frequently results in short-term complications, most commonly lid toxicity, a full course is usually tolerated. Serious complications appear uncommon in the treatment of localised disease.
报告局部非侵袭性眼表鳞状上皮肿瘤（OSSN）在使用局部 5-氟尿嘧啶（5-FU 1%）作为手术切除辅助治疗后的治疗结果。
这是一项前瞻性非对照干预性病例系列研究。对 55 例原发性局部 OSSN 和 10 例复发性局部 OSSN 进行了手术切除、冷冻治疗和辅助 5-FU 1%治疗。在所有病例中，无论手术边缘是否受累，均给予单次 5-FU 1%循环治疗，每天 4 次，连续 2 周。主要观察指标为（1）复发；（2）与辅助局部化疗相关的并发症。对所有患者进行了至少 12 个月的随访。
仅有 1 例（1.5%）复发。57%的患者因 5-FU 1%而出现短期并发症，最常见的是眼睑毒性（49%），其次是浅层角膜炎、溢泪和角膜上皮缺损。有 4 名患者因局部毒性而无法完成 5-FU 1%的疗程。
局部非侵袭性 OSSN 采用辅助 5-FU 1%治疗的局部复发率较低。虽然 5-FU 1%经常导致短期并发症，最常见的是眼睑毒性，但通常可以耐受全疗程。在治疗局限性疾病时，严重并发症似乎并不常见。
