Six Isabelle, Massy Ziad A
Inserm, Facultés de Médecine et de Pharmacie, Amiens, France.
Nephrol Ther. 2010 Feb;6 Suppl 1:S13-8. doi: 10.1016/S1769-7255(10)70006-7.
Vascular calcifications are feature of late stages of atherosclerosis and are associated with cardiovascular disease. Numerous pathologies like diabetes or chronic renal insufficiency were also associated with the development of vascular calcification, particularly in the artery media. In the past, vascular calcifications were considered like a passive and degenerative event. Several studies have allowed demonstrating that they are the results of an active and inflammatory regulated process. A new idea emerges related to the role of calcifications as a cause of inflammation resulting in a vicious circle between inflammation and vascular calcification. This revue proposes to present an update on these different phenomenons.
血管钙化是动脉粥样硬化晚期的特征，与心血管疾病相关。许多疾病，如糖尿病或慢性肾功能不全，也与血管钙化的发展有关，尤其是在动脉中膜。过去，血管钙化被认为是一种被动的退行性事件。多项研究表明，它们是一个活跃的、受炎症调节过程的结果。一个关于钙化作为炎症原因的新观点出现了，这导致了炎症与血管钙化之间的恶性循环。这篇综述旨在介绍这些不同现象的最新情况。
