在荷兰分离的肺炎克雷伯菌中检出一种 Ambler 分类 D 型 OXA-48 型β-内酰胺酶。
Detection of an Ambler class D OXA-48-type β-lactamase in a Klebsiella pneumoniae strain in The Netherlands.
机构信息
Department of Medical Microbiology and Infection Prevention, Saint Lucas Andreas Hospital, Amsterdam, The Netherlands.
Microbiology Laboratory Twente Achterhoek, Enschede, The Netherlands.
出版信息
J Med Microbiol. 2011 May;60(Pt 5):677-678. doi: 10.1099/jmm.0.028308-0. Epub 2011 Jan 20.
Traditionally, bacteria in The Netherlands have low levels of resistance to antibiotics. This report describes what is believed to be the first carbapenem-resistant Klebsiella pneumoniae producing an OXA-48 type β-lactamase in The Netherlands. The isolate co-produced a CTX-M-15 type β-lactamase and was recovered from a patient who was transferred from a hospital in India to an intensive care unit in The Netherlands. His recovery in The Netherlands was complicated by pneumonia due to the carbapenem-resistant K. pneumoniae to which he eventually succumbed. Pre-emptive screening for carbapenem-resistant Enterobacteriaceae in selected patients could be imperative to maintain the low prevalence of these highly resistant bacteria in Dutch hospitals.
传统上，荷兰的细菌对抗生素的耐药性较低。本报告描述了据信在荷兰首次发现产 OXA-48 型β-内酰胺酶的耐碳青霉烯类肺炎克雷伯菌。该分离株同时产生 CTX-M-15 型β-内酰胺酶，从一名从印度一家医院转至荷兰一家重症监护病房的患者身上分离得到。他在荷兰的康复过程因耐碳青霉烯类肺炎克雷伯菌导致的肺炎而变得复杂，最终他因该菌而死亡。对选定患者进行耐碳青霉烯类肠杆菌科细菌的先发筛查对于维持荷兰医院中这些高度耐药细菌的低流行率可能至关重要。
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