Kuwait University, Jabriya, Kuwait. arjuna @ hsc.edu.kw
Med Princ Pract. 2011;20(2):112-7. doi: 10.1159/000321199. Epub 2011 Jan 20.
To evaluate the anti-Candida activity on Candida albicans and Candida dubliniensis species of 2 herbal and 7 other brands of toothpastes commonly used in Kuwait.
Antifungal activity was determined by agar diffusion test on 65 isolates of C. albicans and 21 isolates of C. dubliniensis for each toothpaste. A uniform quantity of toothpaste was filled into wells punched into Sabouraud dextrose agar medium plates inoculated with the test isolates, incubated at 37°C; inhibition zone diameters were read after 24 h.
The mean inhibition zone diameters ranged between 12 and 23 mm for C. albicans and between 12 and 27 mm for C. dubliniensis. A herbal toothpaste brand manufactured in the Middle Eastern region (United Arab Emirates) consisting of many herbal ingredients compared to other brands was found to be the most active (p < 0.001) against both Candida species tested, which also demonstrated higher inhibitory activity against C. dubliniensis isolates compared to C. albicans.
The herbal toothpaste brand presented significant anticandidal activity over conventional toothpastes and may be useful in reducing the pathogenic potential of Candida species.
评估 2 种草本牙膏和 7 种其他品牌的牙膏对白色念珠菌和都柏林念珠菌的抗真菌活性。
对 65 株白色念珠菌和 21 株都柏林念珠菌的每一种牙膏进行琼脂扩散试验，以确定抗真菌活性。将等量的牙膏填充到打孔的琼脂平板培养基的孔中，接种测试分离株，在 37°C 下孵育；孵育 24 小时后，读取抑菌圈直径。
白色念珠菌的平均抑菌圈直径范围为 12 至 23 毫米，都柏林念珠菌的平均抑菌圈直径范围为 12 至 27 毫米。一种由中东地区（阿拉伯联合酋长国）生产的草本牙膏，含有多种草本成分，与其他品牌相比，对两种测试的念珠菌都具有最强的活性（p<0.001），对都柏林念珠菌分离株的抑制活性也高于白色念珠菌。
与传统牙膏相比，这种草本牙膏具有显著的抗真菌活性，可能有助于降低念珠菌属的致病潜能。
