Department of Neurology, Salamanca University Hospital, Salamanca, Spain.
Neuroepidemiology. 2011;36(1):62-8. doi: 10.1159/000323269. Epub 2011 Jan 19.
To describe the design of the baseline assessment of an epidemiological study of elderly persons living in Salamanca, central-western Spain: the Neurological Diseases in Salamanca (NEDISA) study. We assessed the epidemiology of stroke, cognitive disorders, essential tremor (ET), Parkinson's disease (PD) and restless legs syndrome.
In phase 1 (February 1 to May 31, 2007), 4 neurologists and 2 trained general physicians examined and performed phlebotomy on all participants. In phase 2 (June 1, 2007, to June 1, 2008), the participants were reexamined and had a complete neuropsychological assessment. Neuroimaging was performed in participants with cognitive disorders, ET and PD.
The registered study population consisted of 1,077 individuals, but 45 people were ineligible (address change, refusals or death), leaving a final sample of 1,032 (95.8%). The main demographic data on the 1,032 participants (408 men, 624 women) are provided.
Most of the registered study population was enrolled, and this may have been due to the close relationship between NEDISA researchers and the general physicians in the area of study. The NEDISA study will likely improve our knowledge of prevalence rates of the neurological diseases chosen for study as well as the set of risk factors that predispose individuals in Spain to these disorders.
描述西班牙中部萨拉曼卡老年人群流行病学研究的基线评估的设计：神经疾病在萨拉曼卡（NEDISA）研究。我们评估了中风、认知障碍、原发性震颤（ET）、帕金森病（PD）和不宁腿综合征的流行病学。
在第 1 阶段（2007 年 2 月 1 日至 5 月 31 日），4 名神经科医生和 2 名受过培训的全科医生对所有参与者进行了检查和采血。在第 2 阶段（2007 年 6 月 1 日至 2008 年 6 月 1 日），对参与者进行了重新检查，并进行了完整的神经心理学评估。对认知障碍、ET 和 PD 患者进行神经影像学检查。
登记的研究人群包括 1077 人，但有 45 人不符合条件（地址变更、拒绝或死亡），最终样本为 1032 人（95.8%）。提供了 1032 名参与者（408 名男性，624 名女性）的主要人口统计学数据。
已登记的研究人群大部分已入组，这可能是由于 NEDISA 研究人员与研究地区的全科医生之间的密切关系。NEDISA 研究可能会提高我们对所选神经疾病的患病率以及导致西班牙个体易患这些疾病的一系列风险因素的认识。
