特发性震颤中帕金森病和帕金森综合征的发病风险：一项基于人群的研究。

Risk of incident Parkinson's disease and parkinsonism in essential tremor: a population based study.

作者信息

Benito-León J, Louis E D, Bermejo-Pareja F

机构信息

Department of Neurology, University Hospital, Madrid, Spain.

出版信息

J Neurol Neurosurg Psychiatry. 2009 Apr;80(4):423-5. doi: 10.1136/jnnp.2008.147223.

DOI:10.1136/jnnp.2008.147223

PMID:19289477

Abstract

BACKGROUND

A longstanding literature suggests an association between essential tremor (ET) and Parkinson's disease (PD). However, the risk of incident PD has not been quantified in cases of ET compared with controls.

OBJECTIVE

To estimate the risk of incident PD in a population based cohort study of 3813 older people (including ET cases and controls) in central Spain.

RESULTS

After a median of 3.3 years, 12 (5.8%) of 207 ET cases developed parkinsonism compared with 56 (1.6%) of 3606 controls (adjusted relative risk (RR) 3.47, 95% CI 1.82 to 6.59; p<0.001). Six (3.0%) of 201 ET cases developed incident PD versus 24 (0.7%) of 3574 controls (adjusted RR 4.27, 95% CI 1.72 to 10.61; p = 0.002).

CONCLUSIONS

Patients with ET were four times more likely than controls to develop incident PD during prospective follow-up. These data confirm and begin to quantify the link between these two diseases.

摘要

背景

长期以来的文献表明特发性震颤（ET）与帕金森病（PD）之间存在关联。然而，与对照组相比，ET患者发生帕金森病的风险尚未得到量化。

目的

在西班牙中部对3813名老年人（包括ET患者和对照组）进行的基于人群的队列研究中，估计帕金森病的发病风险。

结果

中位随访3.3年后，207例ET患者中有12例（5.8%）出现帕金森综合征，而3606例对照组中有56例（1.6%）出现帕金森综合征（调整相对风险（RR）为3.47，95%置信区间为1.82至6.59；p<0.001）。201例ET患者中有6例（3.0%）发生帕金森病，而3574例对照组中有24例（0.7%）发生帕金森病（调整RR为4.27，95%置信区间为1.72至10.61；p = 0.002）。