三联合征：视觉、听觉和皮质脊髓束病变：HIV 感染患者的一种新综合征。
Triad of visual, auditory and corticospinal tract lesions: a new syndrome in a patient with HIV infection.
机构信息
Department of Neurology, University of Muenster, Germany.
出版信息
AIDS. 2011 Mar 13;25(5):659-63. doi: 10.1097/QAD.0b013e328342fc05.
OBJECTIVE
A case of a rapidly progressive degeneration of the visual, auditory and corticospinal tract in a patient with a HIV infection is presented.
METHODS AND RESULTS
The HIV-infected patient suffered from severe and rapidly progressive sensorineural hearing loss, blindness, dysarthria, dysphagia and tetraparesis. MRI showed degeneration of the visual, auditory and corticospinal tract. Diffusion tensor imaging showed reduced fractional anisotropy of the corticospinal tract. HAART and other salvage therapies did not save the patient from death 5 months after the onset of the symptoms.
CONCLUSION
The triad of auditory, visual and corticospinal lesions has been described in rare syndromes and hereditary diseases. This is the first case of this syndrome associated with a HIV infection.
目的
本文报道了一例 HIV 感染者出现视觉、听觉和皮质脊髓束进行性快速恶化的病例。
方法和结果
该 HIV 感染患者出现严重且快速进展的感觉神经性听力损失、失明、构音障碍、吞咽困难和四肢瘫痪。MRI 显示视觉、听觉和皮质脊髓束变性。弥散张量成像显示皮质脊髓束的各向异性分数降低。高活性抗逆转录病毒治疗（HAART）和其他挽救性治疗未能阻止该患者在症状出现后 5 个月死亡。
结论
听觉、视觉和皮质脊髓束三联征已在罕见综合征和遗传性疾病中有所描述。这是首例与 HIV 感染相关的该综合征病例。
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