Nikiforuk G
Can Fam Physician. 1988 Jun;34:1333-6.
Studies conducted under the widest variety of controlled conditions attest to the safety, efficacy, and cost benefits of fluoridation. A program that combines the use of systemic and topical fluoride results in maximum benefits. The author of this article reviews the metabolism of fluoride and its mechanism of action, and discusses practical modes of employing fluoride in caries prevention with special emphasis on the use of fluoride supplements for infants and young children in areas of non-fluoridated water. The author also discusses the factors responsible for the dramatic decline in caries prevalence in the industrialized nations.
在各种最广泛的受控条件下进行的研究证明了氟化的安全性、有效性和成本效益。结合使用全身用氟和局部用氟的方案可带来最大益处。本文作者回顾了氟的代谢及其作用机制,并讨论了在预防龋齿中使用氟的实际模式,特别强调在非氟化水地区对婴幼儿使用氟补充剂。作者还讨论了工业化国家龋齿患病率大幅下降的原因。