Spak C J, Hardell L I, De Chateau P
Acta Paediatr Scand. 1983 Sep;72(5):699-701. doi: 10.1111/j.1651-2227.1983.tb09796.x.
Reported contents of fluoride (F) in human milk vary considerably. The aim of this study was to determine the F content in human milk under different levels of F intake using a siliconfacilitated microdiffusion technique, which had a good accuracy and precision. The mean F concentration of colostrum from mothers in a 1.0 ppm and a 0.2 ppm F area was 0.36 +/- 0.02 mumol/l (+/- SEM) and 0.28 +/- 0.02 mumol/l, respectively. The mean F concentration of mature milk from a 1.0 ppm F area was 0.37 +/- 0.04 mumol/l. Within the 1.0 ppm F area, the intra- and interindividual differences in F concentration were very small. No statistically significant difference in milk F concentration between the two areas was found. Consequently, breastfed infants living in a 1 ppm or a 0.2 ppm F area will have an approximately equal F intake of 5-10 micrograms per day, in spite of great differences in F intake among the nursing mothers.
母乳中氟化物（F）的报告含量差异很大。本研究的目的是使用硅促进微扩散技术测定不同氟摄入量水平下母乳中的氟含量，该技术具有良好的准确性和精密度。来自氟含量为1.0 ppm和0.2 ppm地区的母亲初乳中氟的平均浓度分别为0.36±0.02 μmol/l（±标准误）和0.28±0.02 μmol/l。来自氟含量为1.0 ppm地区的成熟乳中氟的平均浓度为0.37±0.04 μmol/l。在氟含量为1.0 ppm的地区内，氟浓度的个体内和个体间差异非常小。两个地区母乳中氟浓度未发现统计学上的显著差异。因此，尽管哺乳期母亲的氟摄入量差异很大，但生活在氟含量为1 ppm或0.2 ppm地区的母乳喂养婴儿每天的氟摄入量将大致相等，为5 - 10微克。
