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罗库溴铵诱导儿童过敏反应——1 例报告。

Rocuronium bromide induced anaphylaxis in a child -A case report-.

机构信息

Department of Anesthesiology and Pain Medicine, Pureun Hospital, Daegu, Korea.

出版信息

Korean J Anesthesiol. 2010 Dec;59(6):411-5. doi: 10.4097/kjae.2010.59.6.411. Epub 2010 Dec 31.

DOI:10.4097/kjae.2010.59.6.411
PMID:21253379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3022135/
Abstract

Anaphylaxis or anaphylactoid reaction in pediatric patient during anesthesia is rare. We report a rocuronium induced anaphylactic reaction in a 33-month-old female. The patient was scheduled to undergo escharectomy due to injuries suffered from a major burn. Shortly after administration of rocuronium, the patient developed severe hypotension, tachycardia, and hypoxia. A similar reaction occurred after administration of rocuronium on subsequent anesthesia. She underwent uneventful anesthesia with volatile induction and maintenance of anesthesia with sevoflurane on her next 7 operations without using of muscle relaxant.

摘要

在小儿患者的麻醉期间发生过敏反应或类过敏反应较为罕见。我们报告一例 33 月龄女童因罗库溴铵诱导的过敏反应。该患儿因严重烧伤拟行焦痂切除术。罗库溴铵给药后不久,患儿出现严重低血压、心动过速和缺氧。随后的麻醉中再次给予罗库溴铵时也出现了类似反应。在接下来的 7 次手术中,患儿使用挥发性诱导药物进行麻醉,并用七氟醚维持麻醉,未使用肌松药,过程均较为顺利。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16e/3022135/1ea7a949788c/kjae-59-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16e/3022135/1ea7a949788c/kjae-59-411-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b16e/3022135/1ea7a949788c/kjae-59-411-g001.jpg

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本文引用的文献

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Hypersensitivity reactions to neuromuscular blocking agents.对神经肌肉阻滞剂的过敏反应。
Curr Pharm Des. 2008;14(27):2809-25. doi: 10.2174/138161208786369704.
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Case report: treatment of rocuronium-induced anaphylactic shock with vasopressin.病例报告:用血管加压素治疗罗库溴铵引起的过敏性休克。
Can J Anaesth. 2008 Jul;55(7):437-40. doi: 10.1007/BF03016310.
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Can J Anaesth. 2000 Sep;47(9):890-3. doi: 10.1007/BF03019670.
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