Nephrology Division, Department of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Cardiol Res Pract. 2011 Jan 2;2011:156326. doi: 10.4061/2011/156326.
Starting with the early stages, patients with chronic kidney disease (CKD) experience higher burden of cardiovascular disease (CVD). Moreover, CVD complications are the major cause of mortality in CKD patients as compared with complications from chronic kidney failure. While traditional CVD risk factors, including diabetes, hypertension, hyperlipidemia, obesity, physical inactivity, may be more prevalent among CKD patients, these factors seem to underestimate the accelerated cardiovascular disease in the CKD population. Search for additional biomarkers that could explain the enhanced CVD risk in CKD patients has gained increasing importance. Although it is unlikely that any single nontraditional risk factor would fully account for the increased CVD risk in individuals with CKD, oxidative stress appears to play a central role in the development and progression of CVD and its complications. We will review the data that support the contribution of oxidative stress in the pathogenesis of CVD in patients with chronic kidney failure.
从早期开始，慢性肾脏病 (CKD) 患者就经历着更高的心血管疾病 (CVD) 负担。此外，与慢性肾衰竭并发症相比，CVD 并发症是 CKD 患者死亡的主要原因。虽然包括糖尿病、高血压、高血脂、肥胖、缺乏运动等传统 CVD 危险因素在 CKD 患者中更为普遍，但这些因素似乎低估了 CKD 人群中加速的心血管疾病。寻找可以解释 CKD 患者心血管疾病风险增加的其他生物标志物变得越来越重要。虽然任何单一的非传统危险因素都不太可能完全解释 CKD 个体 CVD 风险的增加，但氧化应激似乎在 CVD 的发生和发展及其并发症中起着核心作用。我们将回顾支持氧化应激在慢性肾衰竭患者 CVD 发病机制中作用的数据。
