Kshatriya Shilpa, Liu Kan, Salah Ali, Szombathy Tamas, Freeman Ronald H, Reams Garry P, Spear Robert M, Villarreal Daniel
Department of Internal Medicine, SUNY Upstate Medical University, Veterans Affairs Medical Center, Syracuse, NY 13210, USA.
Int J Hypertens. 2011 Jan 3;2011:270624. doi: 10.4061/2011/270624.
Leptin is a 16-kDa-peptide hormone that is primarily synthesized and secreted by adipose tissue. One of the major actions of this hormone is the control of energy balance by binding to receptors in the hypothalamus, leading to reduction in food intake and elevation in temperature and energy expenditure. In addition, increasing evidence suggests that leptin, through both direct and indirect mechanisms, may play an important role in cardiovascular and renal regulation. While the relevance of endogenous leptin needs further clarification, it appears to function as a pressure and volume-regulating factor under conditions of health. However, in abnormal situations characterized by chronic hyperleptinemia such as obesity, it may function pathophysiologically for the development of hypertension and possibly also for direct renal, vascular, and cardiac damage.
瘦素是一种16千道尔顿的肽类激素，主要由脂肪组织合成和分泌。该激素的主要作用之一是通过与下丘脑的受体结合来控制能量平衡，从而导致食物摄入量减少以及体温和能量消耗升高。此外，越来越多的证据表明，瘦素通过直接和间接机制，可能在心血管和肾脏调节中发挥重要作用。虽然内源性瘦素的相关性需要进一步阐明，但在健康状况下它似乎起着压力和容量调节因子的作用。然而，在以慢性高瘦素血症为特征的异常情况下，如肥胖症，它可能在高血压的发生发展中发挥病理生理作用，也可能直接导致肾脏、血管和心脏损伤。
