Satish Latha, Kathju Sandeep
Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA.
Dermatol Res Pract. 2010;2010:790234. doi: 10.1155/2010/790234. Epub 2010 Dec 27.
The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. In contrast, fetal wound repair occurs with minimal inflammation, faster re-epithelialization, and without the accumulation of scar. Although research into scarless healing began decades ago, the critical molecular mechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring.
本文的目的是比较和对比胎儿伤口修复与成人伤口修复的离散生物学差异。哺乳动物胎儿的皮肤伤口愈合与成人皮肤伤口愈合本质上不同。成人（出生后）皮肤伤口愈合是一个复杂且精心编排的过程，由伴随的炎症引发，导致伤口闭合并形成疤痕。相比之下，胎儿伤口修复时炎症轻微，再上皮化更快，且不会形成疤痕。尽管对无疤痕愈合的研究始于数十年前，但驱动胎儿再生愈合过程的关键分子机制仍不明确。了解再生愈合过程中的分子和细胞事件可能会提供线索，有朝一日使我们能够调节成人伤口愈合，从而减少疤痕形成。
