无瘢痕与纤维化伤口愈合的细胞和分子特征
Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing.
作者信息
Satish Latha, Kathju Sandeep
机构信息
Center for Genomic Sciences, Allegheny-Singer Research Institute, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, PA 15212, USA.
出版信息
Dermatol Res Pract. 2010;2010:790234. doi: 10.1155/2010/790234. Epub 2010 Dec 27.
Abstract
The purpose of this paper is to compare and contrast the discrete biology differentiating fetal wound repair from its adult counterpart. Integumentary wound healing in mammalian fetuses is essentially different from wound healing in adult skin. Adult (postnatal) skin wound healing is a complex and well-orchestrated process spurred by attendant inflammation that leads to wound closure with scar formation. In contrast, fetal wound repair occurs with minimal inflammation, faster re-epithelialization, and without the accumulation of scar. Although research into scarless healing began decades ago, the critical molecular mechanisms driving the process of regenerative fetal healing remain uncertain. Understanding the molecular and cellular events during regenerative healing may provide clues that one day enable us to modulate adult wound healing and consequently reduce scarring.
摘要
本文的目的是比较和对比胎儿伤口修复与成人伤口修复的离散生物学差异。哺乳动物胎儿的皮肤伤口愈合与成人皮肤伤口愈合本质上不同。成人（出生后）皮肤伤口愈合是一个复杂且精心编排的过程，由伴随的炎症引发，导致伤口闭合并形成疤痕。相比之下，胎儿伤口修复时炎症轻微，再上皮化更快，且不会形成疤痕。尽管对无疤痕愈合的研究始于数十年前，但驱动胎儿再生愈合过程的关键分子机制仍不明确。了解再生愈合过程中的分子和细胞事件可能会提供线索，有朝一日使我们能够调节成人伤口愈合，从而减少疤痕形成。
相似文献
1
Cellular and Molecular Characteristics of Scarless versus Fibrotic Wound Healing.无瘢痕与纤维化伤口愈合的细胞和分子特征
Dermatol Res Pract. 2010;2010:790234. doi: 10.1155/2010/790234. Epub 2010 Dec 27.
2
Understanding Scarring in the Oral Mucosa.了解口腔黏膜瘢痕形成。
Adv Wound Care (New Rochelle). 2022 Oct;11(10):537-547. doi: 10.1089/wound.2021.0038. Epub 2021 Oct 12.
3
A Murine Incisional Fetal Wound-Healing Model to Study Scarless and Fibrotic Skin Repair.一种用于研究无瘢痕和纤维化皮肤修复的鼠切口胎儿创伤愈合模型。
Methods Mol Biol. 2021;2193:13-21. doi: 10.1007/978-1-0716-0845-6_2.
4
Regenerative healing in fetal skin: a review of the literature.胎儿皮肤的再生愈合：文献综述
Ostomy Wound Manage. 2007 Jun;53(6):16-31; quiz 32-3.
5
Scarless fetal skin wound healing update.无瘢痕胎儿皮肤伤口愈合的最新进展。
Birth Defects Res C Embryo Today. 2012 Sep;96(3):237-47. doi: 10.1002/bdrc.21018.
6
Decreased expression of fibroblast and keratinocyte growth factor isoforms and receptors during scarless repair.无瘢痕修复过程中成纤维细胞和角质形成细胞生长因子亚型及其受体的表达降低。
Plast Reconstr Surg. 2003 May;111(6):1969-79. doi: 10.1097/01.PRS.0000054837.47432.E7.
7
Is the future scarless? - Fibroblasts as targets for scarless wound healing: a narrative review.未来会无疤吗？——成纤维细胞作为无疤伤口愈合的靶点：一篇综述
Scars Burn Heal. 2022 Sep 1;8:20595131221095348. doi: 10.1177/20595131221095348. eCollection 2022 Jan-Dec.
9
Scarless integumentary wound healing in the mammalian fetus: molecular basis and therapeutic implications.哺乳动物胎儿无瘢痕皮肤伤口愈合：分子基础及治疗意义
Birth Defects Res C Embryo Today. 2012 Sep;96(3):223-36. doi: 10.1002/bdrc.21015.
10
Cells, matrix, growth factors, and the surgeon. The biology of scarless fetal wound repair.细胞、基质、生长因子与外科医生。胎儿无瘢痕伤口修复的生物学机制。
Ann Surg. 1994 Jul;220(1):10-8. doi: 10.1097/00000658-199407000-00003.
引用本文的文献
1
Local and systemic factors both required for full renewal of deer antlers, and systemic factors only for generic cutaneous regenerative healing.鹿角完全再生需要局部和全身因素，而一般的皮肤再生愈合仅需要全身因素。
Cell Regen. 2025 Jun 10;14(1):24. doi: 10.1186/s13619-025-00233-1.
2
Wound healing potential and anti-inflammatory action of extracts and compounds of Myrciaria plinioides D. Legrand leaves.Myrciaria plinioides D. Legrand 叶的提取物和化合物的伤口愈合潜力和抗炎作用。
Inflammopharmacology. 2024 Oct;32(5):3327-3345. doi: 10.1007/s10787-024-01547-3. Epub 2024 Aug 12.
3
Nanostructured Implant-Tissue Interface Assessment Using a Three-Dimensional Gingival Tissue Equivalent.使用三维牙龈组织等效物评估纳米结构植入物与组织的界面
ACS Omega. 2024 Jul 3;9(28):30534-30543. doi: 10.1021/acsomega.4c02253. eCollection 2024 Jul 16.
4
Regenerative Therapy for Corneal Scarring Disorders.角膜瘢痕疾病的再生疗法
Biomedicines. 2024 Mar 14;12(3):649. doi: 10.3390/biomedicines12030649.
5
Placental stem cells-derived exosomes stimulate cutaneous wound regeneration engrailed-1 inhibition.胎盘干细胞衍生的外泌体刺激皮肤伤口再生并抑制engrailed-1。
Front Bioeng Biotechnol. 2022 Dec 9;10:1044773. doi: 10.3389/fbioe.2022.1044773. eCollection 2022.
6
Impaired healing of cutaneous wound in a Trpv1 deficient mouse.TRPV1 缺陷型小鼠皮肤创伤愈合受损。
Exp Anim. 2023 May 17;72(2):224-232. doi: 10.1538/expanim.22-0124. Epub 2022 Nov 25.
7
Synthesis and Modification of Gelatin Methacryloyl (GelMA) with Antibacterial Quaternary Groups and Its Potential for Periodontal Applications.含抗菌季铵基团的甲基丙烯酸明胶（GelMA）的合成与改性及其在牙周应用中的潜力
Gels. 2022 Oct 5;8(10):630. doi: 10.3390/gels8100630.
8
An Atlas of Optical Coherence Tomography (OCT): Elucidating Differences of Scar Types Using OCT in Order to Guide Laser Treatment Parameters.光学相干断层扫描（OCT）图谱：利用OCT阐明瘢痕类型差异以指导激光治疗参数
J Clin Aesthet Dermatol. 2022 Sep;15(9):30-39.
9
Wound Healing Response After Bleb-Forming Glaucoma Surgery With a SIBS Microshunt in Rabbits.兔眼巩膜下植入引流物(SIBS)微管后小梁切开术的伤口愈合反应。
Transl Vis Sci Technol. 2022 Aug 1;11(8):29. doi: 10.1167/tvst.11.8.29.
10
Evaluation of Platelet-Derived Extracellular Vesicles in Gingival Fibroblasts and Keratinocytes for Periodontal Applications.评价血小板衍生的细胞外囊泡在牙周应用中的牙龈成纤维细胞和角质形成细胞中的作用。
Int J Mol Sci. 2022 Jul 11;23(14):7668. doi: 10.3390/ijms23147668.
本文引用的文献
1
Chaperonin containing T-complex polypeptide subunit eta (CCT-eta) is a specific regulator of fibroblast motility and contractility.热休克蛋白含有 T 复合物多肽亚基 η（CCT-eta）是成纤维细胞运动性和收缩性的特异性调节因子。
PLoS One. 2010 Apr 30;5(4):e10063. doi: 10.1371/journal.pone.0010063.
2
Genetics of keloid scarring.瘢痕疙瘩遗传学。
Arch Dermatol Res. 2010 Jul;302(5):319-39. doi: 10.1007/s00403-009-1014-y. Epub 2010 Feb 4.
3
Upregulation of neurodevelopmental genes during scarless healing.无瘢痕愈合过程中神经发育基因的上调
Ann Plast Surg. 2010 Feb;64(2):247-50. doi: 10.1097/SAP.0b013e3181a20af8.
4
Secondary surgery for cicatricial complications of facial injury.面部损伤瘢痕并发症的二次手术
J Oral Maxillofac Surg. 2010 Apr;68(4):751-5. doi: 10.1016/j.joms.2009.09.026. Epub 2009 Dec 30.
5
Comparison between human fetal and adult skin.人胎儿皮肤与成人皮肤的比较。
Arch Dermatol Res. 2010 Jan;302(1):47-55. doi: 10.1007/s00403-009-0989-8. Epub 2009 Aug 23.
6
Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies.预防性给予阿伏替明以改善皮肤瘢痕形成：三项双盲、安慰剂对照的I/II期研究。
Lancet. 2009 Apr 11;373(9671):1264-74. doi: 10.1016/S0140-6736(09)60322-6.
7
Potential cellular and molecular causes of hypertrophic scar formation.肥厚性瘢痕形成的潜在细胞和分子原因。
Burns. 2009 Feb;35(1):15-29. doi: 10.1016/j.burns.2008.06.020. Epub 2008 Oct 25.
8
Identification of differentially regulated genes in fetal wounds during regenerative repair.再生修复过程中胎儿伤口差异调控基因的鉴定
Wound Repair Regen. 2008 May-Jun;16(3):450-9. doi: 10.1111/j.1524-475X.2008.00383.x.
9
Differential expression of chaperonin containing T-complex polypeptide (CCT) subunits during fetal and adult skin wound healing.含T复合物多肽（CCT）亚基的伴侣蛋白在胎儿和成人皮肤伤口愈合过程中的差异表达。
Cell Stress Chaperones. 2008 Dec;13(4):527-33. doi: 10.1007/s12192-008-0040-6. Epub 2008 May 9.
10
Regulation of scar formation by vascular endothelial growth factor.血管内皮生长因子对瘢痕形成的调控
Lab Invest. 2008 Jun;88(6):579-90. doi: 10.1038/labinvest.2008.36. Epub 2008 Apr 21.
Zotero 插件