Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Photochem Photobiol Sci. 2011 May;10(5):649-52. doi: 10.1039/c0pp00354a. Epub 2011 Jan 21.
Photodynamic therapy (PDT) is an FDA-approved modality for the treatment of early-stage disease and palliation of late-stage disease. Pre-clinical studies using mouse models and clinical studies in patients have demonstrated that PDT is capable of influencing the immune system. The effect of PDT on the generation of anti-tumor immunity is regimen-dependent and is tightly linked to the degree and nature of inflammation induced by PDT. However, the precise mechanism underlying PDT-regulated adaptive anti-tumor immunity remains unclear. This review will focus on the current knowledge of immune regulation by PDT.
光动力疗法 (PDT) 是一种经美国食品药品监督管理局 (FDA) 批准的治疗早期疾病和缓解晚期疾病的方法。使用小鼠模型的临床前研究和患者的临床研究表明,PDT 能够影响免疫系统。PDT 对抗肿瘤免疫的影响取决于方案,并且与 PDT 诱导的炎症程度和性质密切相关。然而,PDT 调节适应性抗肿瘤免疫的确切机制尚不清楚。本文综述将重点介绍 PDT 对免疫调节的最新认识。