Korbelik M
British Columbia Cancer Agency, Vancouver, Canada.
J Clin Laser Med Surg. 1996 Oct;14(5):329-34. doi: 10.1089/clm.1996.14.329.
The mechanism of tumor destruction by photodynamic therapy (PDT) incorporates a variety of events leading to inactivation of tumor cells. The unique feature of PDT is the mobilization of the host to participate in the eradication of treated cancer. A critical element is the induced inflammation at the treated site associated with massive invasion of activated myeloid cells. In addition to further destruction of cancer cells, conditions are created for the presentation of tumor antigens with subsequent activation of lymphoid cells, leading to tumor-specific immunity. This inflammation-primed immune development process results in generation of tumor-specific immune memory cells that appear to be elicited against both strongly and poorly immunogenic PDT-treated cancers. Once generated by PDT, it is conceivable that these immune cells (especially if further expanded and activated by adjuvant immunotherapy) can be engaged in additional eradication of disseminated and/or metastatic lesions of the same cancer. A number of immunotherapy regimens have already been proven effective in enhancing the curative effect of PDT with various animal tumor models. Inflamed cancerous tissue at the PDT-treated site appears to exert powerful attracting signals for immune cells activated by different immunotherapy regimens.
光动力疗法（PDT）破坏肿瘤的机制涉及多种导致肿瘤细胞失活的事件。PDT的独特之处在于动员宿主参与已治疗癌症的根除。一个关键因素是在治疗部位诱导炎症，这与活化髓样细胞的大量浸润有关。除了进一步破坏癌细胞外，还为肿瘤抗原的呈递创造了条件，随后激活淋巴细胞，从而产生肿瘤特异性免疫。这种炎症引发的免疫发育过程导致产生肿瘤特异性免疫记忆细胞，这些细胞似乎是针对免疫原性强和弱的PDT治疗癌症引发的。一旦由PDT产生，可想而知这些免疫细胞（特别是如果通过辅助免疫疗法进一步扩增和激活）可以参与额外根除同一癌症的播散性和/或转移性病变。一些免疫疗法方案已被证明在各种动物肿瘤模型中可有效增强PDT的疗效。PDT治疗部位的炎性癌组织似乎对不同免疫疗法方案激活的免疫细胞发出强大的吸引信号。
