[慢性髓性白血病中细胞色素P4501A1、谷胱甘肽S-转移酶M1和T1基因多态性]
[Cytochrome P4501A1, glutathione S-transferase M1 and T1 gene polymorphisms in chronic myeloid leukemia].
作者信息
Ovsepian V A, Vinogradova E Iu, Sherstneva E S
出版信息
Genetika. 2010 Oct;46(10):1360-2.
Polymorphic variants of cytochrome P4501A1 (CYP1A1), glutathione-S-transferase M1 (GSTM1) and T1 (GSTT1) distribution was studied in patients with chronic myeloid leukemia (CML) and healthy individuals. It was shown that homozygotes for the GSTT1 gene deletion occur significantly more frequently in the CML patient group compared to the control group (13.17% versus 24.10% in CML patients, Chi2 = 4.40, p < 0.05; OR = 2.09; 95% CI = 1.10-3.99). In contrast, no significant difference was observed between the healthy individuals and CML patients in the frequency of polymorphic variants of GSTM1 and CYP1A1 genes (p > 0.05).
在慢性粒细胞白血病（CML）患者和健康个体中，研究了细胞色素P4501A1（CYP1A1）、谷胱甘肽-S-转移酶M1（GSTM1）和T1（GSTT1）的多态性变体分布。结果显示，与对照组相比，GSTT1基因缺失的纯合子在CML患者组中出现的频率显著更高（CML患者中为13.17%，对照组为24.10%，χ2 = 4.4０，p < 0.05；OR = 2.09；95%CI = 1.10 - 3.99）。相反，在健康个体和CML患者中，GSTM1和CYP1A1基因多态性变体的频率未观察到显著差异（p > 0.05）。
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