Imasawa Toshiyuki, Nakazato Takashi
Division of Nephrology, National Hospital Organization Chiba-East Hospital, Chiba, Japan.
Nihon Jinzo Gakkai Shi. 2010;52(8):1015-21.
To improve chronic kidney disease (CKD) outcomes, board-certified nephrologists of the Japanese Society of Nephrology (certified nephrologists) are anticipated to play an important role in community medicine and establish an effective cooperative relationship with primary care physicians. We analyzed the present status of certified nephrologists in each prefecture of Japan based on national data. As a result, in 2008, the maximum number of certified nephrologists per population among the 47 prefectures was 5.3 times higher than the minimum number. The rate of increase was not high in prefectures with a small number of certified nephrologists per population, which indicates that the disparities among the prefectures will persist in the future. To analyze how certified nephrologists participate in the community medicine of the 47 prefectures of Japan, we performed an ecological regression study. At first, it was shown that the number of certified nephrologists per resident population according to prefectures in 2007 had no significant correlation with the annual amount paid for angiotensin converting enzyme inhibitor (ACEI), angiotensin II receptor blocker (ARB), calcium channel-blocker (CCB), or erythropoiesis stimulating agent (ESA) per resident. Furthermore, to determine what parameters had a significant correlation with the incidence of dialysis in each prefecture, simple linear regression analysis was first performed. As a result, parameters with a significant correlation were the average age of the inhabitants, and the annual amounts paid for ARB, ARB plus ACEI, CCB, and ESA per resident. Furthermore, multiple regression analysis revealed that there were two variables included in the final model which could explain the low incidence of dialysis in each prefecture. One was the annual amount of ESA used for predialysis CKD patients, and the other was the number of certified nephrologists per population. Based on these findings, although our ecological study cannot identify causation, we predict that certified nephrologists can effectively prevent the progression of CKD, and an increase in certified nephrologists will decrease the incidence of dialysis.
为改善慢性肾脏病(CKD)的治疗效果,日本肾脏病学会的 board - certified 肾病专家(认证肾病专家)有望在社区医学中发挥重要作用,并与初级保健医生建立有效的合作关系。我们基于全国数据分析了日本各都道府县认证肾病专家的现状。结果显示,2008年,47个都道府县中每人口认证肾病专家的最大数量比最小数量高5.3倍。每人口认证肾病专家数量少的都道府县增长率不高,这表明未来各都道府县之间的差距将持续存在。为分析认证肾病专家如何参与日本47个都道府县的社区医学,我们进行了一项生态回归研究。首先,结果表明2007年各都道府县按居民人口计算的认证肾病专家数量与每位居民用于血管紧张素转换酶抑制剂(ACEI)、血管紧张素II受体阻滞剂(ARB)、钙通道阻滞剂(CCB)或促红细胞生成素(ESA)的年支付金额无显著相关性。此外,为确定哪些参数与各都道府县的透析发病率有显著相关性,首先进行了简单线性回归分析。结果显示,有显著相关性的参数是居民的平均年龄,以及每位居民用于ARB、ARB加ACEI、CCB和ESA的年支付金额。此外,多元回归分析表明,最终模型中有两个变量可以解释各都道府县透析发病率低的情况。一个是用于透析前CKD患者的ESA年用量,另一个是每人口认证肾病专家的数量。基于这些发现,尽管我们的生态研究无法确定因果关系,但我们预测认证肾病专家可以有效预防CKD的进展,认证肾病专家数量的增加将降低透析发病率。