University of California, Department of Dermatology, San Francisco, San Francisco, CA, USA.
J Dermatolog Treat. 2012 Feb;23(1):11-5. doi: 10.3109/09546634.2010.512952. Epub 2011 Jan 22.
Clobetasol 0.05% spray, a topical clobetasol propionate, is a non-greasy formulation that has shown increased clinical efficacy in a head-to-head comparison with foam formulation. Moreover, available data from randomized, controlled, double-blind trials suggests that clobetasol spray is, in fact, slightly more effective than most, if not all, other preparations of clobetasol. The fact that clobetasol spray is exceptionally easy to comply with may have played a major role in this outcome; however, other factors must be considered. These include vehicle metamorphosis post-application as well as vehicle and excipient effects on stratum corneum permeability. Basic concepts in topical drug delivery and how they apply to this spray vehicle may further explain the greater efficacy of clobetasol spray.
倍他米松 0.05% 喷雾剂，一种局部用丙酸倍他米松，是一种非油性配方，与泡沫制剂进行头对头比较显示出更高的临床疗效。此外，来自随机、对照、双盲试验的现有数据表明，倍他米松喷雾剂实际上比大多数（如果不是全部）其他倍他米松制剂更有效。倍他米松喷雾剂非常容易遵守的事实可能在这一结果中起了主要作用；然而，还必须考虑其他因素。这些因素包括应用后载体的形态变化以及载体和赋形剂对角质层渗透性的影响。局部药物输送的基本概念及其如何适用于这种喷雾载体可以进一步解释倍他米松喷雾剂的更高疗效。
