Department of Dermatology, Faculty of Medicine, Yuzuncu yil University, Van, Turkey.
J Dermatolog Treat. 2012 Jun;23(3):168-71. doi: 10.3109/09546634.2010.546831. Epub 2011 Jan 22.
Isotretinoin therapy is associated with numerous adverse effects of various systems. Although some cases have been reported, cardiac side effects are rare following isotretinoin treatment.
To investigate the effects of isotretinoin on the cardiovascular system.
Seventy patients with acne vulgaris were enrolled in the study. The patients were treated with a dose of 0.5-1.0 mg/kg per day of isotretinoin. Screening for biochemical and hematologic parameters, heart rate, blood pressure and electrocardiographic parameters were done before treatment and after 3 months of isotretinoin treatment.
Heart rate, systolic/diastolic tension and electrocardiographic parameters (P-wave duration and QTc duration) were not statistically different before compared with after treatment.
As far as we know, there is no study researching the effect of isotretinoin on P- and QT-wave measurements in the literature. We found that isotretinoin did not affect P- and QT-wave measurement. Further studies with longer periods of follow-up are needed to understand the effect of isotretinoin on the cardiovascular system.
异维 A 酸治疗与各种系统的许多不良反应有关。尽管已有一些病例报道，但异维 A 酸治疗后很少出现心脏副作用。
研究异维 A 酸对心血管系统的影响。
本研究纳入了 70 例寻常痤疮患者。患者每天接受 0.5-1.0mg/kg 的异维 A 酸治疗。在治疗前和异维 A 酸治疗 3 个月后，对生化和血液参数、心率、血压和心电图参数进行筛查。
治疗前后心率、收缩压/舒张压和心电图参数（P 波持续时间和 QTc 持续时间）无统计学差异。
据我们所知，目前文献中尚无研究探讨异维 A 酸对 P 波和 QT 波测量的影响。我们发现异维 A 酸不会影响 P 波和 QT 波的测量。需要进行随访时间更长的进一步研究，以了解异维 A 酸对心血管系统的影响。
