Ay Halil, Aksoy Mustafa, Güngören Fatih
Department of Neurology, Harran University, Şanlıurfa, Turkey.
Department of Dermatology, Harran University, Şanlıurfa, Turkey.
Postepy Dermatol Alergol. 2019 Jun;36(3):291-294. doi: 10.5114/ada.2018.76848. Epub 2018 Jun 29.
The aim of the study was to analyze the potential effects of isotretinoin, frequently used in the treatment of acne vulgaris these days.
For this purpose, we used the methods of sympathetic skin response (SSR) electrophysiological analysis and electrocardiographic (ECG) analysis in patients using isotretinoin. Thirty patients who were diagnosed with acne vulgaris and treated with oral isotretinoin with a dose of 0.5 mg/kg for at least 1 month were included in the study. In all patients ECG scanning and SSR analysis were performed both before treatment and 1 month after the start of treatment.
This study is very important because SSR results show that increasing the existing sympathetic activity in acne vulgaris after isotretinoin usage could explain the exacerbation in acne lesions for the first month, and according to the ECG results the medication did not cause cardiac side effects.
本研究旨在分析如今常用于治疗寻常痤疮的异维A酸的潜在作用。
为此，我们对使用异维A酸的患者采用了交感皮肤反应（SSR）电生理分析和心电图（ECG）分析方法。本研究纳入了30例被诊断为寻常痤疮且口服剂量为0.5mg/kg异维A酸至少1个月的患者。所有患者在治疗前和治疗开始后1个月均进行了心电图扫描和SSR分析。
本研究非常重要，因为SSR结果表明，使用异维A酸后寻常痤疮患者现有的交感神经活动增加可以解释痤疮皮损在第一个月加重的原因，并且根据心电图结果，该药物未引起心脏副作用。
