基于肌动蛋白的运动：WAVE 调节复合物结构重开旧的 SCAR。
Actin-based motility: WAVE regulatory complex structure reopens old SCARs.
机构信息
CR-UK Beatson Institute, Bearsden, Glasgow G61 1BD, UK.
出版信息
Curr Biol. 2011 Jan 25;21(2):R66-8. doi: 10.1016/j.cub.2010.12.001.
PMID:21256435
Abstract
The SCAR/WAVE complex controls actin polymerization at the leading edges of moving cells, but its mechanism of regulation remains unclear. The recent determination of its crystal structure, and identification of the binding sites for upstream regulators, mean its workings can finally start to be revealed.
摘要
SCAR/WAVE 复合物控制着移动细胞前缘的肌动蛋白聚合，但它的调节机制仍不清楚。最近确定了它的晶体结构，并确定了上游调节剂的结合位点，这意味着它的工作机制终于可以开始揭示了。
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