Rivera-Pérez Jaime A, Hadjantonakis Anna-Katerina
Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655.
Developmental Biology Program, Sloan-Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
Cold Spring Harb Perspect Biol. 2014 Jun 26;7(11):a015867. doi: 10.1101/cshperspect.a015867.
SUMMARYOver the past two decades, our understanding of mouse development from implantation to gastrulation has grown exponentially with an upsurge of genetic, molecular, cellular, and morphogenetic information. New discoveries have exalted the role of extraembryonic tissues in orchestrating embryonic patterning and axial specification. At the same time, the identification of unexpected morphogenetic processes occurring during mouse gastrulation has challenged established dogmas and brought new insights into the mechanisms driving germ layer formation. In this article, we summarize the key findings that have reinvigorated the contemporary view of early postimplantation mammalian development.
摘要
在过去二十年中，随着遗传、分子、细胞和形态发生学信息的激增，我们对小鼠从着床到原肠胚形成阶段发育的理解呈指数级增长。新的发现提升了胚外组织在协调胚胎模式形成和轴的特化中的作用。与此同时，小鼠原肠胚形成过程中发生的意外形态发生过程的发现，挑战了既定的教条，并为驱动胚层形成的机制带来了新的见解。在本文中，我们总结了那些重振了当代对植入后早期哺乳动物发育观点的关键发现。
