与T细胞亚群改变及自然杀伤活性降低相关的特发性心肌炎。

Idiopathic myocarditis associated with T-cell subset changes and depressed natural killer activity.

作者信息

Kanda T, Ohshima S, Yuasa K, Watanabe T, Suzuki T, Murata K

机构信息

Department of Cardiology, Gunma University School of Medicine, Japan.

出版信息

Jpn Heart J. 1990 Sep;31(5):741-4. doi: 10.1536/ihj.31.741.

DOI:10.1536/ihj.31.741

PMID:2125666

Abstract

A 65-year-old man with idiopathic myocarditis is described. He was admitted with symptoms of acute heart failure. Examination revealed left ventricular hypokinesis. Results of an endomyocardial biopsy showed "resolving myocarditis". Immunological studies of the peripheral blood showed a low helper-suppressor (CD4/CD8) ratio on admission and depressed natural killer (NK) cell activity coincident with the onset of myocarditis. We considered that this immunological imbalance may have occurred during the progression of myocarditis to dilated cardiomyopathy.

摘要

本文描述了一名65岁的特发性心肌炎男性患者。他因急性心力衰竭症状入院。检查发现左心室运动功能减退。心内膜心肌活检结果显示为“正在消退的心肌炎”。外周血免疫研究显示，入院时辅助性T细胞与抑制性T细胞（CD4/CD8）比值较低，且自然杀伤（NK）细胞活性降低，这与心肌炎发作同时出现。我们认为这种免疫失衡可能发生在心肌炎进展为扩张型心肌病的过程中。