Stroffolini T, Angelini L, Galanti I, Occhionero M, Congiu M E, Mastrantonio P
Laboratorio di Epidemiologia, Istituto Superiore di Sanità, Roma, Italy.
Microbiologica. 1990 Jul;13(3):225-9.
The effect of Neisseria meningitidis group A and C polysaccharide vaccine on nasopharyngeal carriage was studied in Italian army recruits. Throat swabs were cultured for N. meningitidis at the time of vaccination (one week after entry to service) and again three weeks later in a follow-up cohort of 98 men. At the first survey the overall carriage rate was 32% with 9% of isolates due to serogroup C, none to serogroup A and 17% to serogroup Y. At the second survey the overall carriage rate reached 52% (P less than 0.01); no isolate belonged to serogroup A or C, while serogroup Y reached 40% (P less than 0.01). The cumulative carriage rate was 65%. Out of the 64 carriers during the whole study period, only 7 (11%) belonged to the same serogroup during the two different surveys. The vaccination appears to influence the carriage rate of meningococcal specific serogroups. The inhibition of serogroups A and C is, however, offset by an increased prevalence of meningococci belonging to serogroup Y.
在意大利新兵中研究了A群和C群脑膜炎奈瑟菌多糖疫苗对鼻咽部带菌情况的影响。在接种疫苗时（入伍一周后）采集咽喉拭子培养脑膜炎奈瑟菌，三周后在98名男性的随访队列中再次采集。在首次调查中，总体带菌率为32%，其中9%的分离株属于C群，无A群分离株，17%属于Y群。在第二次调查中，总体带菌率达到52%（P<0.01）；无分离株属于A群或C群，而Y群达到40%（P<0.01）。累积带菌率为65%。在整个研究期间的64名带菌者中，只有7名（11%）在两次不同调查中属于同一血清群。疫苗接种似乎影响脑膜炎奈瑟菌特定血清群的带菌率。然而，A群和C群的抑制作用被Y群脑膜炎球菌患病率的增加所抵消。
