Exner T, Papadopoulos G, Sahman N, Koutts J
Hematology Department, Westmead Hospital, Sydney, Australia.
Thromb Haemost. 1990 Aug 13;64(1):121-3.
Phospholipid procoagulant material mainly derived from platelets interferes or "bypasses" the more specific tests for lupus anticoagulants. Such material in test plasmas can be inactivated with recovery of lupus anticoagulant activity by simple extraction with chloroform. This solvent treatment damages mainly factors VIII, V, VII and IX. Ether and various other solvents were less damaging to these clotting factors but not quite as effective as chloroform in the recovery of lupus anticoagulant activity.
主要来源于血小板的磷脂促凝物质会干扰或“绕过”针对狼疮抗凝物的更特异性检测。通过用氯仿简单提取，检测血浆中的此类物质可被灭活，同时狼疮抗凝物活性得以恢复。这种溶剂处理主要损害因子VIII、V、VII和IX。乙醚及其他各种溶剂对这些凝血因子的损害较小，但在恢复狼疮抗凝物活性方面不如氯仿有效。
