Rosner E, Pauzner R, Lusky A, Modan M, Many A
Thromb Haemost. 1987 Apr 7;57(2):144-7.
Sixty-six SLE patients were studied for the presence of lupus type circulating anticoagulant. Forty-nine percent of them showed activity of this anticoagulant. The sensitivity of various coagulation tests was compared. Recalcification time was found to be the most sensitive screening test and the kaolin clotting time mixture test, the best for determining the presence of the anticoagulant. Tissue thromboplastin inhibition test detected only half of the patients in whom the anticoagulant was found by recalcification time and kaolin clotting time mixture test. APTT, using 2 different reagents, resulted in 73% and 52% false negatives. A numerical index for determining the presence of the anticoagulant and its quantitative evaluation is suggested. The association between thromboembolic events, recurrent abortions and the different coagulation tests is shown.
对66例系统性红斑狼疮（SLE）患者进行狼疮型循环抗凝物质检测。其中49%的患者显示出这种抗凝物质的活性。比较了各种凝血试验的敏感性。发现复钙时间是最敏感的筛查试验，而白陶土凝血时间混合试验是确定抗凝物质存在的最佳试验。组织凝血活酶抑制试验仅检测出通过复钙时间和白陶土凝血时间混合试验发现有抗凝物质的患者中的一半。使用2种不同试剂的活化部分凝血活酶时间（APTT）分别导致73%和52%的假阴性。提出了一种用于确定抗凝物质存在及其定量评估的数值指标。显示了血栓栓塞事件、反复流产与不同凝血试验之间的关联。
