British Columbia Cancer Agency, Vancouver, BC, Canada.
Photochem Photobiol Sci. 2011 May;10(5):664-9. doi: 10.1039/c0pp00343c. Epub 2011 Jan 24.
The development of photodynamic therapy (PDT)-generated cancer vaccines is potentially one of the most significant achievements in the field of PDT. Employing vaccine protocols optimizes the capacity of PDT of inducing a strong immune response against treated tumor due to the establishment of highly favourable conditions for maximizing the avidity of the immune reaction while sustaining and prolonging its tumor-destroying attack. While the introduction of PDT vaccines into the clinics and testing on patients is still in a very early phase, much work can still be done on further improvement of the potency of PDT vaccines. Considerable advances can be expected by identifying the most effective adjuvants to be used with PDT vaccines, which will most likely be different with different types of cancerous lesions.
光动力疗法（PDT）生成癌症疫苗的发展可能是 PDT 领域最重大的成就之一。采用疫苗方案可以优化 PDT 诱导针对治疗肿瘤的强烈免疫反应的能力，因为它为最大限度地提高免疫反应的亲合力创造了有利条件，同时维持和延长其对肿瘤的破坏攻击。虽然 PDT 疫苗在临床上的引入和对患者的测试仍处于非常早期的阶段，但仍有大量工作可以进一步提高 PDT 疫苗的效力。通过确定与 PDT 疫苗一起使用的最有效的佐剂，可以预期取得相当大的进展，而这些佐剂很可能因不同类型的癌性病变而有所不同。
