Barna J S, Frable M A
Department of Otolaryngology-Head and Neck Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Otolaryngol Head Neck Surg. 1990 Nov;103(5 ( Pt 1)):795-8. doi: 10.1177/019459989010300521.
Angioedema is a well-recognized edema involving the deeper layers of the skin, subcutaneous tissue, and mucosa. From July 1986 to July 1989 the authors have observed and treated 10 patients admitted to the Medical College of Virginia (MCV) Hospitals in Richmond, Virginia, with life-threatening angioedema as a complication of enalapril or captopril ingestion. Both drugs are angiotensin-converting enzyme (ACE) inhibitors prescribed for antihypertensive activity and the ability to improve symptoms in patients with congestive heart failure. We describe the clinical symptoms, diagnosis, and management of these patients, as well as reasons for each occurrence. Sporadic reports of angioedema secondary to ACE inhibitor therapy have appeared in the literature. This represents the first time a significant series of patients from the same institution have encountered this complication over a short period of time, suggesting that the complication may be much more common than has been thought.
血管性水肿是一种公认的累及皮肤深层、皮下组织和黏膜的水肿。1986年7月至1989年7月，作者观察并治疗了10例因服用依那普利或卡托普利而出现危及生命的血管性水肿并发症、入住弗吉尼亚州里士满市弗吉尼亚医学院医院（MCV医院）的患者。这两种药物都是血管紧张素转换酶（ACE）抑制剂，用于抗高血压活性以及改善充血性心力衰竭患者的症状。我们描述了这些患者的临床症状、诊断和治疗，以及每次发病的原因。文献中曾出现过关于ACE抑制剂治疗继发血管性水肿的零星报道。这是首次有同一机构的大量患者在短时间内遭遇这一并发症，表明该并发症可能比人们认为的更为常见。
