Sordoillet C, Chauvin M A, Guillaumot P, Ghiglieri C, de Peretti E, Loras B, Mauduit C, Morera A M, Benahmed M
Groupe de Recherches sur les Communications Cellulaires, Hôpital Sainte-Eugénie, C.H. Lyon-Sud, Pierre-Bénite, France.
Pathol Biol (Paris). 1990 Nov;38(9):923-7.
Testicular function is regulated not only by circulating hormones, among which the gonadotrophins play the main role, but also by local factors originating in multiple and complex interactions among cells. In this review, the example of gonadotrophins (LH and FSH) and Transforming Growth Factor beta (TGF beta) was chosen to illustrate the role of interactions between circulating hormones and gonadal growth factors in testicular function control; TGF beta-like activity has been found in the male gonad and we have used a model of cultured purified testicular cells to show that the action of TGF beta on testicular function mainly involves antagonism of the effect of gonadotrophins. Conversely, TGF beta promotes differentiated Leydig and Sertoli cell function. The example of interactions between TGF beta and gonadotrophins reported here shows that locally produced growth factors can regulate the response of testicular cells to gonadotrophins, a finding that extends our concept of reproductive endocrinology to cell-cell interactions.
睾丸功能不仅受循环激素的调节（其中促性腺激素起主要作用），还受细胞间多种复杂相互作用产生的局部因素的调节。在本综述中，选择促性腺激素（LH和FSH）以及转化生长因子β（TGFβ）的例子来说明循环激素与性腺生长因子之间的相互作用在睾丸功能控制中的作用；在雄性性腺中已发现TGFβ样活性，并且我们使用培养的纯化睾丸细胞模型表明，TGFβ对睾丸功能的作用主要涉及对促性腺激素作用的拮抗。相反，TGFβ促进睾丸间质细胞和支持细胞的分化功能。此处报道的TGFβ与促性腺激素之间相互作用的例子表明，局部产生的生长因子可调节睾丸细胞对促性腺激素的反应，这一发现将我们的生殖内分泌学概念扩展到细胞间相互作用。
