Lejeune H, Avallet O, Saez J M
INSERM-INRA U307, Hôpital Debrousse, Lyon.
Contracept Fertil Sex. 1994 Sep;22(9):539-47.
The existence of multiple interactions between somatic cells in the testis, has been suspected in vivo, and demonstrated in vitro by cocultures and cultures in the presence of conditioned media. Long term Sertoli-Leydig cell interactions results in a local regulation of the specific differentiated functions of these cells, and more precisely in a control of their responsiveness to their respective gonadotropin. Among the paracrine and/or autocrine factors, growth factors are involved in the control of differentiated functions. It is the case for IGF-I and TGF-beta, which respectively exhibit a stimulatory and inhibitory effect on Leydig cell functions and more specifically on LH responsiveness.
睾丸中体细胞之间存在多种相互作用，这在体内已被怀疑，并通过共培养和在条件培养基存在下的培养在体外得到证实。支持细胞-间质细胞的长期相互作用导致这些细胞特定分化功能的局部调节，更确切地说是控制它们对各自促性腺激素的反应性。在旁分泌和/或自分泌因子中，生长因子参与分化功能的控制。胰岛素样生长因子-I（IGF-I）和转化生长因子-β（TGF-β）就是这种情况，它们分别对间质细胞功能，更具体地说是对促黄体生成素（LH）反应性表现出刺激和抑制作用。
