Bunce M, Sutton P M, Ting A, Morris P J
Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, U.K.
Tissue Antigens. 1990 Sep;36(3):100-2. doi: 10.1111/j.1399-0039.1990.tb01808.x.
By use of the heterohybridoma technique we have produced a human monoclonal antibody (NDS40) which detects a split of HLA-DRw13 (DRw13b) which is in linkage with HLA-DQw1. In addition, the antibody reacts with cells positive for HLA-DRw8 and DRw11, but does not react with the commonly found split of DRw13 (DRw13a) which is associated with DQw1. NDS40 is cytotoxic and is of the lambda IgM class.
通过使用异种杂交瘤技术，我们制备了一种人单克隆抗体（NDS40），它可检测到与HLA - DQw1连锁的HLA - DRw13（DRw13b）的一个亚群。此外，该抗体与HLA - DRw8和DRw11阳性的细胞发生反应，但不与常见的与DQw1相关的DRw13亚群（DRw13a）发生反应。NDS40具有细胞毒性，属于λIgM类。
