Darke C, Street J
Blood Transfusion Centre, Cardiff, Wales, U.K.
Tissue Antigens. 1987 Jul;30(1):42-7. doi: 10.1111/j.1399-0039.1987.tb01595.x.
A lymphocytotoxic HLA-DR alloantiserum (Ma159) which reacts with DR7, DR5 and DRw13 positive lymphocytes is described. It was non-cytotoxic against 27 DRw14 positive subjects and was not absorbed by DRw14 positive cells. The antiserum was produced by pregnancy alone in a DR4, DRw14 positive woman whose husband possesses DR7 and DRw13. Absorption and titration studies suggested that the antiserum contains separate antibodies directed towards DR7, DRw13 and a determinant shared by DR5 and DRw13. The implications of finding a specific anti-DRw13 antiserum and its production in a donor positive for the alternative subdivision of DRw6 are discussed.
本文描述了一种淋巴细胞毒性HLA - DR同种抗血清（Ma159），它能与DR7、DR5和DRw13阳性淋巴细胞发生反应。该抗血清对27名DRw14阳性个体无细胞毒性，且不被DRw14阳性细胞吸收。此抗血清是由一名DR4、DRw14阳性的妇女在怀孕时产生的，其丈夫拥有DR7和DRw13。吸收和滴定研究表明，该抗血清含有分别针对DR7、DRw13以及DR5和DRw13共有的一个决定簇的抗体。文中讨论了发现一种特异性抗DRw13抗血清及其在DRw6替代亚群阳性供体中产生的意义。
