Skin Cancer Unit, Nantes University Hospital, Nantes, France.
J Eur Acad Dermatol Venereol. 2011 Oct;25(10):1146-52. doi: 10.1111/j.1468-3083.2010.03934.x. Epub 2011 Jan 24.
Zinc is a cofactor of many metalloenzymes explaining that it plays a crucial role in cell proliferation and also in the regulation of immune system. It has been shown by different data that it could play a crucial role not only in the regulation of adaptative immunity but also in innate immunity which plays a crucial role in skin.
In this article, we proposed an overview of published information in the literature, on zinc and cutaneous innate immunity.
At the basic level, we gave a synthesis of data related to zinc's cutaneous targets in innate immunity, and then at clinical level selected studies on cutaneous disorders where zinc could be a therapeutic approach and discussed the targets of zinc in these pathologies.
RESULTS/CONCLUSION: The specific activity of zinc salts on the innate immunity of the skin with different targets can explain why zinc is more specifically involved in cutaneous affection in which inflammation plays a particular important role, such as inflammatory acne, acrodermatitis enteropathica, hidradenitis suppurativa, folliculitis decalvans.
锌是许多金属酶的辅助因子，这表明它在细胞增殖以及免疫系统调节中起着至关重要的作用。不同的数据表明，锌不仅在适应性免疫调节中起着至关重要的作用，而且在先天免疫中也起着至关重要的作用，先天免疫在皮肤中起着至关重要的作用。
本文对文献中已发表的关于锌与皮肤先天免疫的信息进行了综述。
在基础水平上，我们对锌在先天免疫中的皮肤靶目标相关数据进行了综合，然后在临床水平上选择了关于锌可能作为治疗方法的皮肤疾病的研究，并讨论了锌在这些疾病中的作用靶点。
结果/结论：锌盐对不同靶标的皮肤先天免疫的特异性活性可以解释为什么锌更具体地参与了炎症起特别重要作用的皮肤疾病，如炎症性痤疮、肠病性肢端皮炎、化脓性汗腺炎、滤泡性脱发。
