Nakane A, Numata A, Minagawa T
Department of Microbiology, Hokkaido University School of Medicine, Sapporo, Japan.
Immunology. 1990 Dec;71(4):560-5.
The effects of 15-deoxyspergualin (DSG), an immunosuppressive agent, on host resistance against Listeria monocytogenes were studied in mice. Administration of DSG in the early phase of infection resulted in fatal listeriosis by preventing acquired anti-listerial resistance, even though the infectious dose was sublethal for the untreated controls. In contrast, DSG treatment started after development of the acquired immunity was ineffective. Endogenous production of interferon-gamma (IFN-gamma) and tumour necrosis factor (TNF) in the bloodstreams induced by the infection was normal in DSG-treated mice. Nevertheless, augmentation of macrophage functions such as expression of major histocompatibility complex (MHC) class II antigens, phagocytic activity and listericidal activity induced by the infection was abrogated by DSG treatment. These results suggest that the inhibitory effect of DSG on anti-listerial resistance might be different from cyclosporine A (CsA).
研究了免疫抑制剂15-脱氧精胍菌素（DSG）对小鼠抵抗单核细胞增生李斯特菌宿主抵抗力的影响。在感染早期给予DSG，即使感染剂量对未处理的对照小鼠是亚致死性的，也会因阻止获得性抗李斯特菌抵抗力而导致致命的李斯特菌病。相反，在获得性免疫形成后开始的DSG治疗无效。在接受DSG治疗的小鼠中，感染诱导的血液中内源性γ-干扰素（IFN-γ）和肿瘤坏死因子（TNF）的产生正常。然而，DSG治疗消除了感染诱导的巨噬细胞功能增强，如主要组织相容性复合体（MHC）II类抗原的表达、吞噬活性和杀菌活性。这些结果表明，DSG对抗李斯特菌抵抗力的抑制作用可能与环孢素A（CsA）不同。
