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基于 QD 的肿瘤微环境定量多重成像揭示的癌症浸润模式。

Patterns of cancer invasion revealed by QDs-based quantitative multiplexed imaging of tumor microenvironment.

机构信息

Department of Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors and Hubei Cancer Clinical Study Center, No. 169 Donghu Road, Wuchang District, Wuhan 430071, PR China.

出版信息

Biomaterials. 2011 Apr;32(11):2907-17. doi: 10.1016/j.biomaterials.2010.12.053. Epub 2011 Jan 22.

Abstract

Tumor growth and progression depends on their microenvironment, which undergoes constant co-evolution because of the dynamic tumor-stormal interactions. Such co-evolution has long been under appreciated due to the lack of appropriate technology platforms to simultaneously reveal these complex interactions. Here we report on a quantum dots based multiplexed imaging and spectrum analysis technology to simultaneously study major components of tumor stroma, including type IV collagen, tumor angiogenesis, macrophages infiltration and tissue destructive proteolytic enzyme matrix metalloproteinase 9. The new technology revealed a panoramic picture of the tempo-spatial co-evolution of tumor cells and their stroma at the architecture level. Four patterns of tumor invasion with distinctive co-evolution features were identified as Washing pattern, Ameba-like pattern, Polarity pattern and Linear pattern. This quantum dots based multiplexed technology could help gain new insight into the complex process of tumor invasion, and formulate new anti-cancer strategies.

摘要

肿瘤的生长和进展取决于其微环境,由于肿瘤-基质的动态相互作用,微环境不断协同进化。由于缺乏适当的技术平台来同时揭示这些复杂的相互作用,这种协同进化长期以来一直被低估。在这里,我们报告了一种基于量子点的多重成像和光谱分析技术,该技术可同时研究肿瘤基质的主要成分,包括 IV 型胶原、肿瘤血管生成、巨噬细胞浸润和组织破坏性蛋白酶基质金属蛋白酶 9。这项新技术在结构水平上揭示了肿瘤细胞及其基质在时空调控上协同进化的全景图。鉴定出四种具有独特协同进化特征的肿瘤浸润模式,分别为冲洗模式、阿米巴样模式、极性模式和线性模式。这种基于量子点的多重技术可以帮助我们深入了解肿瘤浸润的复杂过程,并制定新的抗癌策略。

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