Department for Companion Animals and Horses, Clinic for Small Animals and Infectious Diseases, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Vet Rec. 2010 Dec 25;167(26):997-1001. doi: 10.1136/vr.c4010.
To establish reference intervals for the urinary corticoid:creatinine ratio (UCCR) determined by chemiluminometric immunoassay, UCCR was measured by this method in 50 healthy dogs. To assess the diagnostic performance of different cut-off levels, the UCCR of 66 dogs with hyperadrenocorticism and 87 dogs with diseases mimicking hyperadrenocorticism were used to construct a receiver operating characteristic (ROC) curve. The upper reference limit derived from morning samples in healthy dogs was 30.81 × 10(-6). The area under the ROC curve was 0.94. The diagnostic cut-off with the highest negative likelihood ratio was 26.5 × 10(-6) (sensitivity 1, specificity 0.54), whereas the cut-off with the highest positive likelihood ratio was 161.2 × 10(-6) (specificity 0.988, sensitivity 0.515). The application of these two different diagnostic cut-offs eliminated the necessity to perform additional tests in 53 per cent of the patient population.
为了建立化学发光免疫分析法测定尿皮质醇肌酐比值（UCCR）的参考区间，我们用该方法测定了 50 只健康犬的 UCCR。为了评估不同截断值的诊断性能，我们用 66 只库欣氏病犬和 87 只类似库欣氏病的疾病犬的 UCCR 构建了受试者工作特征（ROC）曲线。健康犬早晨样本的 UCCR 上限参考值为 30.81×10(-6)。ROC 曲线下面积为 0.94。具有最高负似然比的诊断截断值为 26.5×10(-6)（敏感性为 1，特异性为 0.54），而具有最高正似然比的截断值为 161.2×10(-6)（特异性为 0.988，敏感性为 0.515）。这两个不同诊断截断值的应用使 53%的患者人群无需进行额外的检查。
