不使用地高辛特异性抗体（Fab）片段的自杀性地高辛中毒的临床特征及成功处理——这可行吗？

Clinical features and successful management of suicidal digoxin toxicity without use of digoxin-specific antibody (Fab) fragments--is it possible?

作者信息

Sanaei-Zadeh Hossein, Valian Zahra, Zamani Nasim, Farajidana Hoorvash, Mostafazadeh Babak

机构信息

Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Niayesh Street, Sattar-Khan Avenue, 1445613131, Tehran, Iran.

出版信息

Trop Doct. 2011 Apr;41(2):108-10. doi: 10.1258/td.2010.100195. Epub 2011 Jan 24.

DOI:10.1258/td.2010.100195

PMID:21262953

Abstract

A retrospective study of 147 consecutive cases of suicidal digoxin poisoning was undertaken in order to determine the severity and outcome of toxicity without use of digoxin-specific Fab fragments. This study showed that suicidal digoxin poisoning in young patients is usually mild to moderate; even underlying cardiac disease and chronic use of digoxin has no effect on the severity of toxicity and incidence of lethal dysrhythmia in these cases. This type of toxicity responds appropriately to conventional treatment.

摘要

为了确定在不使用地高辛特异性Fab片段的情况下中毒的严重程度和结果，对147例连续的自杀性地高辛中毒病例进行了回顾性研究。这项研究表明，年轻患者的自杀性地高辛中毒通常为轻度至中度；即使存在潜在的心脏病和长期使用地高辛，对这些病例中毒的严重程度和致命性心律失常的发生率也没有影响。这种类型的中毒对传统治疗反应良好。