Dluzen D E, Ramirez V D
Department of Physiology and Biophysics, University of Illinois, Urbana.
Neuroendocrinology. 1990 Nov;52(5):517-20. doi: 10.1159/000125637.
Previous work from our laboratory has indicated that a direct infusion of progesterone (P) into superfusion chambers containing corpus striatum (CS) tissue fragments of ovariectomized/estrogen-treated female rats augmented amphetamine-stimulated dopamine release in vitro. In this report, we examine whether this phenomenon is also present in the male rat. Only in castrated male rats treated with estrogen were we able to demonstrate an increase in amphetamine-stimulated dopamine release in response to a direct infusion of P. Intact and castrated male rats treated with testosterone propionate or vehicle failed to show any significant differences in response to P. These results demonstrate that the CS of male rats can respond to P only if males are exposed to an estrogenic hormonal milieu and indicate an absence of a sexually dimorphic response of the CS to P.
我们实验室之前的研究表明，将孕酮（P）直接注入含有去卵巢/雌激素处理的雌性大鼠纹状体（CS）组织碎片的灌注室中，可增强体外苯丙胺刺激的多巴胺释放。在本报告中，我们研究了这种现象是否也存在于雄性大鼠中。只有在用雌激素处理的去势雄性大鼠中，我们才能证明直接注入P后，苯丙胺刺激的多巴胺释放增加。用丙酸睾酮或赋形剂处理的完整和去势雄性大鼠对P的反应没有任何显著差异。这些结果表明，只有当雄性大鼠暴露于雌激素环境中时，其纹状体才能对P作出反应，这表明纹状体对P不存在性别二态性反应。
