Dluzen D E, Anderson L I
Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272-0095, USA.
Neurosci Lett. 1997 Jul 18;230(2):140-2. doi: 10.1016/s0304-3940(97)00487-4.
In the present experiment we examined the effects of an in vitro infusion of nicotine (10 microM) upon dopamine release from superfused striatum of castrated male and female rats treated or not treated with estrogen. Estrogen exerted bidirectional effects on nicotine-evoked dopamine release as a function of the sex of the animal. Nicotine-evoked dopamine release was increased in estrogen treated females and decreased in estrogen treated males. Peak nicotine-evoked dopamine output from estrogen treated females was significantly greater than that of estrogen treated males. These results may be related to the gender differences in response to nicotine and smoking behavior.
在本实验中，我们研究了体外注入尼古丁（10微摩尔）对经或未经雌激素处理的去势雄性和雌性大鼠的灌注纹状体中多巴胺释放的影响。雌激素对尼古丁诱发的多巴胺释放产生双向影响，这取决于动物的性别。在经雌激素处理的雌性大鼠中，尼古丁诱发的多巴胺释放增加，而在经雌激素处理的雄性大鼠中则减少。经雌激素处理的雌性大鼠中尼古丁诱发的多巴胺输出峰值显著高于经雌激素处理的雄性大鼠。这些结果可能与对尼古丁和吸烟行为反应的性别差异有关。
