细胞核在骨骼肌消耗中的结构和功能改变：原位证据。
Structural and functional alterations of the cell nucleus in skeletal muscle wasting: the evidence in situ.
机构信息
Dipartimento di Scienze Neurologiche, Neuropsicologiche, Morfologiche e Motorie, Sezione di Anatomia e Istologia, Università di Verona, Italy.
出版信息
Eur J Histochem. 2010 Oct 19;54(4):e44. doi: 10.4081/ejh.2010.e44.
Abstract
The histochemical and ultrastructural analysis of the nuclear components involved in RNA transcription and splicing can reveal the occurrence of cellular dysfunctions eventually related to the onset of a pathological phenotype. In recent years, nuclear histochemistry at light and electron microscopy has increasingly been used to investigate the basic mechanisms of skeletal muscle diseases; the study in situ of nuclei of myofibres and satellite cells proved to be crucial for understanding the pathogenesis of skeletal muscle wasting in sarcopenia, myotonic dystrophy and laminopathies.
摘要
核成分在 RNA 转录和剪接中的组织化学和超微结构分析可以揭示与病理表型发生相关的细胞功能障碍的发生。近年来，在光镜和电子显微镜下的核组织化学已越来越多地用于研究骨骼肌疾病的基本机制；对肌纤维和卫星细胞核的原位研究对于理解在少肌症、强直性肌营养不良和层粘连蛋白病中的骨骼肌萎缩的发病机制至关重要。
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