核酸研究的组织化学：《欧洲组织化学杂志》60 年。
Histochemistry for nucleic acid research: 60 years in the European Journal of Histochemistry.
机构信息
Laboratory of Cell Biology and Neurobiology, Department of Biology and Biotechnology, University of Pavia.
出版信息
Eur J Histochem. 2022 Apr 20;66(2):3409. doi: 10.4081/ejh.2022.3409.
Since the discovery of DNA structure in 1953, the deoxyribonucleic acid has always been playing a central role in biological research. As physical and ordered nucleotides sequence, it stands at the base of genes existence. Furthermore, beside this 2-dimensional sequence, DNA is characterized by a 3D structural and functional organization, which is of interest for the scientific community due to multiple levels of expression regulation, of interaction with other biomolecules, and much more. Analogously, the nucleic acid counterpart of DNA, RNA, represents a central issue in research, because of its fundamental role in gene expression and regulation, and for the DNA-RNA interplay. Because of their importance, DNA and RNA have always been mentioned and studied in several publications, and the European Journal of Histochemistry is no exception. Here, we review and discuss the papers published in the last 60 years of this Journal, focusing on its contribution in deepening the knowledge about this topic and analysing papers that reflect the interest this Journal always granted to the world of DNA and RNA.
自 1953 年发现 DNA 结构以来，脱氧核糖核酸一直是生物研究的核心。作为物理有序的核苷酸序列，它是基因存在的基础。此外，除了这个二维序列，DNA 还具有三维结构和功能组织的特征，由于多个表达调控水平、与其他生物分子的相互作用等，这一特征引起了科学界的兴趣。类似地，DNA 的核酸对应物 RNA，在基因表达和调控方面发挥着重要作用，并且在 DNA-RNA 相互作用中也起着重要作用。由于它们的重要性，DNA 和 RNA 一直是在许多出版物中被提及和研究的，《欧洲组织化学杂志》也不例外。在这里，我们回顾和讨论了该杂志在过去 60 年中发表的论文，重点讨论了其在加深对该主题的认识方面的贡献，并分析了反映该杂志一直对 DNA 和 RNA 世界感兴趣的论文。
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