单克隆抗体。
Monoclonal antibodies.
出版信息
Can Fam Physician. 1987 Feb;33:369-72.
The development of hybridoma monoclonal antibody (MAb) technology has had a major impact on clinical and laboratory medicine. It has allowed the production of essentially unlimited quantities of pure, homogeneous antibodies against a large variety of antigens. Despite the many advantages of MAbs, the effort and expense required for their production is not always justified. Less expensive and more easily obtained conventional anti-serum is still perfectly adequate in some instances. Nevertheless, murine MAbs have found widespread use in clinical and research laboratories, particularly in the field of oncology. Considerable effort has been devoted to the development of human MAbs, since antibodies of human origin are expected to be superior in therapeutic and in vivo diagnostic settings. However, technical difficulties currently prevent their widespread use. Finally, novel approaches using genetic engineering techniques are described, which portend exciting new developments in the near future.
杂交瘤单克隆抗体 (MAb) 技术的发展对临床和实验室医学产生了重大影响。它使得大量生产针对各种抗原的纯、同质抗体成为可能。尽管 MAb 具有许多优点，但生产它们所需的努力和费用并不总是合理的。在某些情况下，更便宜、更容易获得的常规抗血清仍然完全足够。然而，鼠源 MAb 已在临床和研究实验室中得到广泛应用，特别是在肿瘤学领域。人们致力于开发人源 MAb，因为预期人源抗体在治疗和体内诊断方面更具优势。然而，目前技术上的困难阻碍了它们的广泛应用。最后，描述了使用基因工程技术的新方法，这些方法预示着在不久的将来将有令人兴奋的新发展。
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